I've long maintained that William Burroughs is my anti-drug.
Back when I was maybe 14 years old I had exhausted everything William Gibson had published, but I read an interview someplace where he cited William Burroughs as one of his literary influences. So I started reading Burroughs, which then of course led to Kerouac, Ginsberg, et al. From the Beats it was a logical progression to read books by Tim Leary and his crowd, progress on down the timeline to Terrence McKenna, and then come full circle from there back to cyberpunk via Douglas Rushkoff. Anyway, my Burroughs takeaway was: avoid opioids.